Treatment of vaginal trichomoniasis with a new anti-protozoal compound ( -chloromethyl-2-methyl-5-nitro-1-imidazole-ethanol).

Ro 7-0207 is a light yellow, crystalline substance with a melting range of 74-79oC. The pH of a 1 per cent. aqueous solution is about 6-6. In water its solubility is 2-4 per cent. at 25°C. In 95 per cent. ethanol its solubility is > 50 per cent. at 25GC. Aqueous solutions (0-5 per cent.) are relatively stable upon heating at 100GC. for 1 hr. except at pH values above 7. Ro 7-0207 is an effective antiprotozoal agent in experimental infections of rats, hamsters, and mice. It also showed marked activity against Entamoeba histolytica in both intracaecal infection in rats and hepatic infection in hamsters when administered orally, and against hepatic infection when administered subcutaneously. It was also markedly active when administered orally against local and systemic Trichomonas vaginalis and Trichomonas foetus infections in mice. The substance showed moderate activity against T. vaginalis when administered by infiltration at the site of infection.